iPrEx OLE (OLE stands for Open Label Extension) is a continuation of the iPrEx study designed to provide additional information about the safety of PrEP and the behavior of people taking PrEP over a longer term. It is hoped that participants’ knowledge that Truvada PrEP provides some protection against HIV infection, and the fact that all HIV-negative participants in iPrEx OLE know that they are receiving Truvada PrEP and not a placebo, will lead to increased use of the study drug by participants in iPrEx OLE, and increased protection against HIV infection.
iPrEx OLE will take place at 11 sites in Peru, Ecuador, Brazil, the United States, South Africa and Thailand. Click here for additional information on the iPrEx OLE study sites.

| Lima | |
| Iquitos | |
| Guayaquil | |
| San Francisco | |
| Boston | |
| Chicago | |
| São Paulo | |
| Rio de Janeiro | |
| Chiang Mai | |
| Cape Town |